Systemic Sclerosis Crest :: medcyber.com
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Systemic sclerosis is also known as scleroderma, SSc, diffuse scleroderma, dSSc, limited scleroderma, lSSc, and CREST Syndrome. It can affect the skin, blood vessels, and internal organs. Scleroderma is a rare and complex autoimmune connective tissue disease that can potentially affect all organ systems. Technically, scleroderma is an aspect of systemic sclerosis, a systemic connective tissue disease that involves subcutaneous tissue, muscles, and internal organs. 07.08.2018 · CREST calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia syndrome is a member of the heterogeneous group of sclerodermas, and its name is an acronym for the cardinal clinical features of the syndrome. In 1910, Thibierge and Weissenbach described the first case report of what was later called CRST calc. CREST is a type of systemic sclerosis or scleroderma, an autoimmune condition. Autoimmune means that the immune system, the body’s natural defence against infections, produces unhelpful proteins called antibodies that target healthy tissues.

In diffuse cutaneous systemic scleroderma, the condition worsens quickly and organ damage occurs earlier than in other types of the condition. In the third type of systemic scleroderma, called systemic sclerosis sine scleroderma "sine" means without in Latin, fibrosis affects one. Systemic sclerosis, otherwise known as Scleroderma, is a rare connective tissue disorder. Although the etiology is not fully elucidated, systemic sclerosis is considered to be an autoimmune disease. The condition is characterized by a variable degree of systemic manifestations, including fibrosis affecting multiple organs system; and telangiectasias and abnormalities of the digestive system.

The CREST syndrome refers to a disorder comprising the manifestations of calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia. Thirteen CREST patients two with CRST were compared with 26 patients with systemic sclerosis but without the full manifestations of the CRST syndrome. Systemic sclerosis is a rare multisystem disorder characterised by vascular abnormalities, connective tissue sclerosis and atrophy, and the presence of autoantibodies. There is both cutaneous and systemic involvement, with gastrointestinal, respiratory, cardiac, and. Limited Scleroderma – CREST Syndrome. Limited scleroderma means only limited areas of skin are thick; usually just the fingers and/or face. Limited scleroderma is the milder form of scleroderma. It is more common among Caucasians than other populations. Every person with scleroderma is different and has a different pattern of symptoms.

Systemic scleroderma can be further divided into limited or diffuse categories; the NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases adds a third category: systemic sclerosis sine, which does not feature the more overt skin changes 1 2. Scleroderma has been further subclassified into localized scleroderma morphea, limited cutaneous systemic sclerosis previously CREST syndrome, standing for calcinosis, Raynaud’s phenomenon, esophageal dysmotility, sclerodactyly, telangiectasias and diffuse cutaneous systemic sclerosis.

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